ncRNA name | hsa-miR-19a |
ncRNA Category | miRNA |
Disease name | diabetic retinopathy (DR) |
Species | Homo sapiens |
Tissues/Cell_line | peripheral B cells |
Methods | qRT-PCR, Western blot, ELISA, chromatin immunoprecipitation (ChIP), RNAi |
Expression pattern | up-regulated |
Functional description | miR-19a was increased in B cells of DR patients, which was negatively correlated with the IL-10 expression. Exposure of naive B cells to IL-17 increased the expression of miR-19a and suppression of IL-10 expression in the B cells, in which histone deacetylase 11 (HDAC 11) played a critical role. |
PubMed ID | 28386366 |
Year | 2017 |
Title | Micro RNA-19a suppresses interleukin-10 in peripheral B cells of patients with diabetic retinopathy. |
Drug-related ncRNA | NO |
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