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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name hsa-miR-19a
ncRNA Category miRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line peripheral B cells
Methods qRT-PCR, Western blot, ELISA, chromatin immunoprecipitation (ChIP), RNAi
Expression pattern up-regulated
Functional description miR-19a was increased in B cells of DR patients, which was negatively correlated with the IL-10 expression. Exposure of naive B cells to IL-17 increased the expression of miR-19a and suppression of IL-10 expression in the B cells, in which histone deacetylase 11 (HDAC 11) played a critical role.
PubMed ID 28386366
Year 2017
Title Micro RNA-19a suppresses interleukin-10 in peripheral B cells of patients with diabetic retinopathy.
Drug-related ncRNA NO

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